ORY-1001 trans and cis isomers
CAS No. 1431326-61-2
ORY-1001 trans and cis isomers ( RG 6016;RG6016;RG-6016;ORY1001;ORY 1001 )
Catalog No. M11827 CAS No. 1431326-61-2
ORY-1001 (RG-6016) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 68 | In Stock |
|
5MG | 122 | In Stock |
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10MG | 221 | In Stock |
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25MG | 428 | In Stock |
|
50MG | 626 | In Stock |
|
100MG | 889 | In Stock |
|
500MG | 1782 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameORY-1001 trans and cis isomers
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NoteResearch use only, not for human use.
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Brief DescriptionORY-1001 (RG-6016) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM.
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DescriptionORY-1001 (RG-6016) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases; exhibits low nanomolar cellular activity (EC50 < 1 nM) in the THP1 differentiation assay and induces the CD11b marker within 6 hr of treatment in FACS based differentiation assay in THP1 cell line; induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML; exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of AML xenograft models.Blood Cancer Phase 2 Clinical
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SynonymsRG 6016;RG6016;RG-6016;ORY1001;ORY 1001
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorLSD1/KDM1A
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1431326-61-2
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Formula Weight303.27
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Molecular FormulaC15H24Cl2N2
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Purity>98% (HPLC)
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SolubilityDMSO: < 6.8 mg/mL
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SMILESNC1CCC(N[C@@H]2C[C@H]2C3=CC=CC=C3)CC1.Cl.Cl
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Chemical Name1,4-Cyclohexanediamine, N1-[(1R,2S)-2-phenylcyclopropyl]-, hydrochloride (1:2), rel-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maes T, et al. Cancer Cell. 2018 Mar 12;33(3):495-511.e12.
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